Lrp8 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comLrp8 Polyclonal Antibody for Mouse(Mus musculus)

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Lrp8 (Gene name),

Low-density lipoprotein receptor-related protein 8 (Protein name ), LRP8_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Lrp8(Apoer2);

Protein name:

Low-density lipoprotein receptor-related protein 8(LRP-8);

Alternative:

Apolipoprotein E receptor 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Reelin associates with two or more receptor molecules. Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17.

Function:

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Secreted Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.

Protein Attributes:

Sequence length:

996

Sequence:

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996:

PALKELFVLP | GEPRSQLHQL | PKNPLSELPV | VKCKRVALSL | EDDGLP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.442134

String:

Q924X6

Pfam:

PF07645

SMR:

Q924X6

Uniprot:

Q924X6

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ELISA Kit for Mouse LRP-8

Cat.:

E10006h

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Packing:

96T

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ELISA Kit for Mouse LRP-8

MSDS:

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ELISA Kit for Mouse LRP-8

Cat.:

E10006m

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96T

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CLIA Kit for Mouse LRP-8

MSDS:

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CLIA Kit for Mouse LRP-8

Cat.:

U10006h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse LRP-8

Cat.:

U10006m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse LRP-8

Cat.:

P10006Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse LRP-8

Monoclonal Antibody for Mouse LRP-8

Protein for Mouse LRP-8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Evolution of the apolipoprotein E receptor 2 gene by exon loss."
Kim H.-J. , Kim D.-H. , Magoori K. , Saeki S. , Yamamoto T.
J. Biochem.124:451-456(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha2-macroglobulin."
Brandes C. , Kahr L. , Stockinger W. , Hiesberger T. , Schneider W.J. , Nimpf J.
J. Biol. Chem.276:22160-22169(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING;INTERACTION WITH REELIN AND ALPHA2-MACROGLOBULIN
3.

"The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor."
Stockinger W. , Sailler B. , Strasser V. , Recheis B. , Fasching D. , Kahr L. , Schneider W.J. , Nimpf J.
EMBO J.21:4259-4267(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX17
4.

"Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase."
May P. , Bock H.H. , Nimpf J. , Herz J.
J. Biol. Chem.278:37386-37392(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;GLYCOSYLATION;PROTEOLYTIC PROCESSING
5.

"A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling."
Koch S. , Strasser V. , Hauser C. , Fasching D. , Brandes C. , Bajari T.M. , Schneider W.J. , Nimpf J.
EMBO J.21:5996-6004(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;PROTEOLYTIC PROCESSING
6.

"Essential role of the apolipoprotein E receptor-2 in sperm development."
Andersen O.M. , Yeung C.H. , Vorum H. , Wellner M. , Andreassen T.K. , Erdmann B. , Mueller E.C. , Herz J. , Otto A. , Cooper T.G. , Willnow T.E.
J. Biol. Chem.278:23989-23995(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SPERM DEVELOPMENT
7.

"Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2."
Trommsdorff M. , Gotthardt M. , Hiesberger T. , Shelton J. , Stockinger W. , Nimpf J. , Hammer R.E. , Richardson J.A. , Herz J.
Cell97:689-701(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB1
8.

"The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2."
Stockinger W. , Brandes C. , Fasching D. , Hermann M. , Gotthardt M. , Herz J. , Schneider W.J. , Nimpf J.
J. Biol. Chem.275:25625-25632(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JNK-INTERACTING PROTEINS;TISSUE SPECIFICITY
9.

"Differential binding of ligands to the apolipoprotein E receptor 2."
Andersen O.M. , Benhayon D. , Curran T. , Willnow T.E.
Biochemistry42:9355-9364(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAP AND REELIN;STOICHIOMETRY;MUTAGENESIS

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